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our results Marshall and Jones (1995) focus on model selection using models with covariates Their resulting survival curve, adjusted for covariates, gives the following results: The probability of remaining free of total blindness for 5 years (60 months) beginning with no retinopathy is approximately 096, and for 10 years (120 months) it is 077 Yau and Huzurbazar (2002) use a owgraph model with different assumptions They retain the Marshall and Jones (1995) assumption that censored observations are assumed to have transited to the worst state This affects their choice of branch waiting time distributions In this analysis we have allowed censored observations to have a mixture distribution over the possible transitions to both the better and worse states Yau and Huzurbazar (2002) present a owgraph analysis based only on maximum likelihood.

to accumulate in cells of aquatic organisms treated with contaminants (Wolfe et al, 1981; Aloj Totaro et al, 1986; Pipe & Moore, 1986; Viarengo, 1989; Cajaraville et al, 1990; Moore, 1990; Krishnakumar et al, 1995) In sh, Aloj Totaro et al (1986) have reported an increased formation of lipofuscins in the nervous tissue of Torpedo marmorata upon copper exposure More recently, applying quantitative morphometric methods, Au et al (1999) found increased lipofuscin granules in the hepatocytes of Solea ovata injected with benzo[a]pyrene The increased number of lipofuscin granules were suggested to be linked to increased lipid peroxidation driven by ROS produced during redox cycling of benzo[a]pyrene quinone metabolites The occurrence of lipid peroxidation in biological membranes causes impaired membrane functioning, decreased membrane uidity, inactivation of membrane bound receptors and enzymes and increased non-speci c permeability to ions such as calcium (Gutteridge & Halliwell, 1990).

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Yau and Huzurbazar (2002) nd that the probability of remaining free of total blindness for 5 years (60 months) beginning with no retinopathy is approximately 099, and for 10 years (120 months) it is just under 090 The maximum likelihood results here indicate that the probability of remaining free of blindness for 5 years is similar, 0991 75, and for 10 years it is 0918 74 Yau and Huzurbazar (2002) nd that the corresponding survival times for 096 and 077 are 85 months and 183 months, respectively The maximum likelihood analysis performed here has survival times of 93 months and 204 months for survivor function values of 096 and 077 The Bayesian analysis of the owgraph model gives the probability of remaining free of blindness for 5 years beginning with no retinopathy as 0990 52, and for 10 years as 0.

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902 46 The survival time corresponding to survivor function values of 096 and 077 are approximately 87 months and 188 months Even if the comparison were to a Markov model without covariates, we would expect both the owgraph survival times to be longer because our parametric models are based on much heavier-tailed distributions In addition, the Bayes predictive distribution will have more spread Although not directly comparable, the owgraph model results are also in agreement with those presented in related studies of diabetic retinopathy such as Klein et al (1984a, b) Table 74 gives a comparison of the waiting times for each branch among the actual data (uncensored only) and the MLEs for the uncensored data and the.

It is widely accepted that pollutant-induced ROS can initiate or promote lipid peroxidation (Comporti, 1985; Brunk & Cadenas, 1988; Farber et al, 1990; Gutteridge & Halliwell, 1990) For instance, heavy metal-induced lipid peroxidation has been reported extensively for transition metals, especially copper and iron, and to a lesser extent lead and zinc Radi and Matkovics (1988) have reported increased lipid peroxidation in carp (Cyprinus carpio) exposed to copper and zinc and similar results have been found for gilthead seabream (Sparus aurata) injected with polar xenobiotics, copper and paraquat (Pedrajas et al, 1995) This has also been reported in rainbow trout (Oncorhynchus mykiss) treated with endosulphan and disulphoton simultaneously (Arnold et al, 1995) In addition, there is evidence that exposure to PAHs can result in lipid peroxidation in sh such as channel cat sh (Ictalurus punctatus) and dab (Limanda limanda) (Di Giulio et al.

since the cost savings may reach $25,000. Controller, government, 500 employees, Texas. Streamline Back-Office Overhead by Automating the Benefits Function. Challenge: Action: Implement a human resources information system (HRIS) system successfully. Our new automated HRIS system allows us to process, track, and record information quicker, as well as to provide management reports faster. Since implementation, we have brought the preparation of employee benefits statements in-house. We have also reduced work we formerly outsourced to vendors. We estimate our approximate yearly cost savings at $15,000 to $30,000. Assistant controller, manufacturing, 1,300 employees, Wisconsin.

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